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Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus. Antimicrobial Agents and Chemotherapy ;41 3 Other important effects of glycyrrhizin and glycyrrhizinic acid have been reported to have cardioprotective, hepatoprotective and plasma lipid-lowering effects Fuhrman et al. Antiatherosclerotic effects of licorice extract supplementation on patients: Increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure.

Nutrition ;18 3 Mae T. Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A y mice. Biological and Pharmaceutical Bulletin ; Hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra Linn in rats. Studies on the effects of triterpenoid saponins and flavonoid compounds possessed by licorice root on human and experimental animals have been intensified in recent years.

In the same study, licorice root was reported to improve hepatic HMG-CoA reductase activity, prevent lipid peroxidation by increasing the amount of superoxide dismutase SOD and catalase enzyme. Nitalikar et al. Studies of antibacterial activities of Glycyrrhiza glabraroot extract. International Journal of Pharm Tech Research ;2 1 Sen et al. Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats. Journal of Pharmacy and Pharmacology ; Karami et al. Effect of harvest time on antioxidant activity of Glycyrrhiza glabraroot extract and evaluation of its antibacterial activity.

International Food Research Journal ;20 5 The studies conducted using licorice root was carried out especially with broiler chickens, but limited number of studies were found for the effect of it on laying hens. For this purpose, in the present study, the effects of bioactive compounds contained in the licorice plant were investigated on the performance and on some plasma lipid profile of lipid metabolism in terms HDL, LDL, total cholesterol and total triglyceride levels of laying hens.

In addition, the effects of the plant on antioxidant status of the hens were revealed with total antioxidant and oxidant status TAS and TOS parameters. At the same time, the effect of licorice to the cholesterol content of the eggs was also determined. A total of Lohman Brown laying hens at 40 week of age with an initial body weight range between The hens were weighed individually and divided into four groups of 25 hens each and housed individually in 55cmx50cmx45cm battery cages equipped with nipple drinkers.

The basic ingredient and chemical composition of commercial diet is shown in Table 1. Licorice root was obtained from Hatay province which is situated in southern Turkey, on the eastern Mediterranean coast. The latitude of Hatay is The experiment lasted 8 weeks. During the study, feeds were given daily to hens in individual cages and weekly feed consumption was calculated by taking advantage of daily feed consumption. The individual weekly feed consumption was divided by the individual weekly egg weight, and the individual feed conversion ratio was calculated.

During the experiment, eggs were collected daily from the cage and weighed with a scale of 0. Egg yields were calculated by recording the number of eggs collected daily. At the 4 th and 8 th weeks of the experiment, egg yolk cholesterol levels were analyzed by collecting 15 eggs from each experimental group. Fat extraction from samples was performed according to the method developed by Boselli et al.

The solution obtained at the end of the period was filtered clean tube by vacuum filtration method. Egg yolk cholesterol levels were estimated by spectrophotometric method using the Boehringer Manheim GmbhBiochemica To determine the effect of licorice root on some plasma parameters and antioxidant capacity, eight randomly selected animals from each group were chosen at the end of the experiment and blood samples were taken from the brachial wing vein. Blood samples were placedin EDTA anticoagulant tubes and centrifuged for 10 minutes at rpm to separate plasma from whole blood.

Plasma glucose levels and plasma lipid profiles HDL, LDL, total cholesterol, total triglyceride of the samples were tested spectrophotometrically according to the protocols of commercial kits Erba Mannheim, CZ. At the end of the study, total antioxidant and oxidant status TAS and TOS parameters were detected in plasma samples taken from eight randomly selected animals from each group.

The effect of licorice root on oxidant stress and the antioxidant system were determined by oxidative stress index by measuring the total antioxidant and oxidant status TAS and TOS parameters. The oxidative stress index is equal to the percentage of total oxidant status to total antioxidant status. Increased oxidative stress in children exposed to passive smoking.

International Journal of Cardiology ; The effects of licorice root supplement on performance of laying hens are shown in Table 2. The body weights at the beginning of the experiment were set to be similar to each other and body weights varied between However, body weights at the end of the study were reduced with increasing level of licorice root supplement to diets. At the end of the experiment, body weights were determined as The highest feed consumption was obtained as to be The decrease in feed consumption with the addition of licorice root between the hens may be due to the aromatic odor of the plant.

Indeed, Fiore et al. Rezaei et al. Thymus vulgaris L. Researchers investigated the effects of Thymus vulgaris L. Effect of dietary licorice extract on some physiological and productive traits of Ross broiler chicken. International Journal of Current Research ;8 8 They stated that the other licorice root extract on supplemented groups 1. Moradi et al. Performance and some immunological parameter responses of broiler chickens to licorice Glycyrrhiza glabra extract administration in the drinking water.

The individual and augmentative effects of these two extracts were tested for their narrow range effective lower concentration on PC-3M in clonogenic assays. At relatively lower concentrations, C. However, when both the agents were tested together at the same concentrations, the combined effects were much more significant than their individual ones. On normal prostate epithelial cells both C. These observations were confirmed by several cytotoxicity assays involving the morphological appearance of the colonies, microscopic observations, per cent inhibition in comparison to control by sulforhodamine B and tetrazolium dye assay.

Conclusions From these observations, it was concluded that the combined effects of C. Antiparasitic efficacy of curcumin from Curcuma longa against Ichthyophthirius multifiliis in grass carp. Ichthyophthirius multifiliis Ich is a ciliated parasite that elicits great economic losses in aquaculture.

In the present study, a polyphenol compound, curcumin, was obtained from the rhizome of Curcuma longa by bioassay-guided isolation based on the efficacy of anti-Ich theronts. Anti-Ich efficac Antunes, S. Sao Paulo Univ. The mullet Mugilidae is a fish caught in large quantities in brackish and marine waters of the southern Brazilian coast, which in consequence of its raw consumption as ''sashimi'', a typical Japanese dish, has led to ten cases of human infection by Phagicola longa in Sao Paulo, Brazil.

The mullet acts as a second intermediate host for the parasite, as in human heterophyiasis in the Near and Far East.

In order to control these infections under commercial storage conditions and in raw consumption, the radiolysis of P. It was observed that 1. The parasite motility decreased in the grey mullet treated with doses of 2. This dose also controls other metacercaria found in the ''parati-pema'', without changing the odor, color or appearance of the treated mullet.

All compounds had strong in The present research was aimed at verifing the effect of different periods of ultraviolet light on the development of the symbiont fungus of leaf cutting ants belonging to the species Acromyrmex ambiguus, Acromyrmex crassispinus and Acromyrmex lundi, through the AFLP technique. After that, they were exposed to ultraviolet light for 0, 5, 10, 15, 20, 25, and 30 minutes.

At 45 days after the treatment, the extraction and standardization of DNA was performed. Endophytes from medicinal plants represent a potential source of bioactive compounds. During the present investigation, fungal endophytes were isolated from turmeric Curcuma longa , an important medicinal plant.

A total of endophytic fungal isolates were obtained from the rhizome of C. They were grouped into seven genera based on morphological and molecular data. The fungal endophytes of C. The disease is a major cause for economic loss in turmeric cultivation. Endophytic Phoma herbarum showed significant activity against C. A compound gentisyl alcohol was isolated from P.

The organism could therefore be used as a biocontrol agent against C. All the strains produced IAA and solubilized phosphate and only two strains pr Curcumin longa extract-loaded nanoemulsion improves the survival of endotoxemic mice by inhibiting nitric oxide-dependent HMGB1 release.

High mobility group box 1 HMGB1 is a well-known damage-related alarmin that participates in cellular inflammatory responses. However, the mechanisms leading to HMGB1 release in inflammatory conditions and the therapeutic agents that could prevent it remain poorly understood.

This study attempted to examine whether the Curcumin longa herb, which is known to have anti-inflammatory property, can modulate cellular inflammatory responses by regulating HMGB1 release. The murine macrophage RAW We have shown that a nanoemulsion loaded with an extract from the C.

First, treatment of RAW The nanoemulsion did not affect LPS-induced p38 or extracellular signal-regulated kinase activation. Second, intraperitoneal administration of the nanoemulsion improved the survival rate of LPS-injected endotoxemic mice. The present study shows for the first time the mechanism by which C. These observations suggest that identification of.

Full Text Available Background High mobility group box 1 HMGB1 is a well-known damage-related alarmin that participates in cellular inflammatory responses. Methods The murine macrophage RAW Results We have shown that a nanoemulsion loaded with an extract from the C. Discussion The present study shows for the first time the mechanism by which C. Green synthesis of ZnO nanoparticles via complex formation by using Curcuma longa extract.

Fatimah, Is, E-mail: isfatimah uii. Kaliurang Km 14, Sleman, Yogyakarta Indonesia. Curcuma longa extract has the ability to form zinc ions complex with curcumin as ligating agent. Study on synthesis was conducted by monitoring thermal degradation of the material.

Successful formation of zinc oxide nanoparticles was confirmed by employing x-ray diffraction, surface area analysis and transmission electron microscopy TEM studies. From the XRD analysis it is denoted that ZnO in hexagonal wurtzite phase was formed and particle size was varied as varied temperature.

The data are also confirmed by TEM analysis which shows the particle sie at the range nm. The NPs exhibited excelent photocatalytic activity for methylene blue degradation and also significant antibacterial activity for Eschericia coli. The activity in methylene blue degradation was also confirmed from fast chemical oxygen demand COD reduction. Objective s : The effects of Curcuma longa C.

Results: Total and mo Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. To evaluate the hepatoprotective and immunotherapeutic effects of aqueous extract of turmeric rhizome in CCl4 intoxicated Swiss albino mice. The third group was given both the turmeric extract for 15 days, orally and CCl4 for last 7 days, i.

The fourth group was kept as a control. For assaying the immunotherapeutic action of Curcuma longa C. Apart from damaging the liver system, CCl4 also reduced non specific host response parameters like morphological alteration, phagocytosis, nitric oxide release, myeloperoxidase release and intracellular killing capacity of peritoneal macrophages. Administration of aqueous extract of C.

In conclusion, the present study suggests that C. The mullet acts as a second intermediate host for the parasite, as in human heterophysiasis in the Near and Far East. This dose also controls other metacercaria found in the "parati-pema", without changing the odor, color or appearance of the treated mullet. Alexandre Grandazzi, Alba Longa.

Il libro di A. Grandazzi si segnala per le dimensioni e per la portata della ricerca : circa mille pagine, distribuite su due volumi di pari ampiezza, sviluppano, per la prima volta in modo esaustivo, il vessato problema storiografico relativo alla genesi della leggenda romana di Alba Longa.

The process currently used by most agricultural producers for drying Curcuma longa L. Under these drying conditions, in an ambient with practically no temperature and moisture control, various problems can arise, such as an excessively long time to reach desired moisture content, with the concomitant growth of microorganisms harmful to health and high product.

Full Text Available En este trabajo se evaluaron las actividades antioxidantes in vitro de los aceites esenciales de Origanum vulgare L.

Full Text Available Intake of food and nutrition plays a major role in affecting aging process and longevity. However, the precise mechanisms underlying the ageing process are still unclear. To this respect, diet has been considered to be a determinant of ageing process. In order to better illustrate this, we used Drosophila melanogaster as a model and fed them orally with different concentrations of two commonly used Indian medicinal plant products, Curcuma longa rhizome and Emblica officinalis fruit.

The results revealed significant increase in life span of Drosophila flies on exposure to both the plant products, more efficiently by C.

Longa than by E. In order to understand whether the increase in lifespan was due to high-antioxidant properties of these medicinal plants, we performed enzymatic assays to assess the SOD and catalase activities in case of both treated and control Drosophila flies. Interestingly, the results support the free radical theory of aging as both these plant derivatives show high reactive oxygen species ROS scavenging activities.

Isolation and spectroscopic studies of curcumin from Philippine Curcuma longa L. Curcumin, the yellow coloring matter was isolated from the rhizomes of Philippine Curcuma longa L. The isolated curcumin was then subjected to chromatographic and spectroscopic studies with the Merck curcumin standard. The infra red and UV-vis spectra of both compounds were found to be almost identical indicating a high purity of the isolate. Previous studies on turmeric oil reported effective antifungal activity against dermatophytes, a group of fungi that causes skin diseases.

Minimum fungicidal concentratio Full Text Available Turmeric and ginger are spices derived from the rhizomes of Curcuma longa and Zingiber officinale respectively. The rhizomes of C. Phytochemical screening was carried out on each of the extracts. Proximate analysis to determine the extractive values, moisture content, total ash, crude fibre, acid insoluble ash and water soluble ash were carried out on the rhizomes of fresh and dried turmeric and ginger.

Extractive values for ginger were recorded as alcohol 2. Observations on the microscopic studies of the fresh rhizomes of turmeric and ginger revealed possession of oil duct and spiral xylem vessels. Similarly phytomorphology of the powdered rhizomes of ginger and turmeric revealed the presence of tracheid and compartment of vessels. Presence of similar anatomical features in both the fresh and ground samples confirmed the authenticity or adulterous of the powdered samples.

This study aimed to determine cephalometric characteristics of long face pattern patients in comparison to Class I pattern patients. A total of 73 lateral norm telerradiographs, 34 long face pattern and 39 Class I pattern individuals, were selected and compared with regards to facial morphology, not considering occlusal and sagital relationships.

Additionally, evaluations were also made on facial growth pattern, anterior. Full Text Available A simple high performance thin layer chromatographic HPTLC method has been developed for the simultaneous determination of the pharmacologically important active Curcuminoids viz.

Using this technique, the alkaloidal content of different parts of the title plant has been determined. Termitarium-Inhabiting Bacillus spp. Curcumin diferuloyl methane is the main bioactive component of turmeric Curcuma longa L. Both the strains showed remarkable PGP activities and also chemotactic in nature with high chemotactic index. Turmeric plants bacterized with strains B. High-performance liquid chromatography analysis was performed to determine the content of curcumin, which showed concentration of curcumin in un-inoculated turmeric as 3.

Full Text Available Promastigote forms of Leishmania amazonensis were treated with different concentrations of two fractions of Curcuma longa cortex rich in turmerones and their respective liposomal formulations in order to evaluate growth inhibition and the minimal inhibitory concentration MIC. In addition, cellular alterations of treated promastigotes were investigated under transmission and scanning electron microscopies.

Parasite growth inhibition was demonstrated to be dose-dependent. Important morphological changes as rounded body and presence of several roles on plasmatic membrane could be seen on L. In that sense, the hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation LipoRHIC could represent good strategy for the development of new antileishmanial agent.

Amaral, Ana Claudia F. Promastigote forms of Leishmania amazonensis were treated with different concentrations of two fractions of Curcuma longa cortex rich in turmerones and their respective liposomal formulations in order to evaluate growth inhibition and the minimal inhibitory concentration MIC. Vertical distribution, feeding and vulnerability to tactile predation in Metridia longa Copepoda, Calanoida.

We assessed the vertical distribution and feeding of the calanoid copepod Metridia longa in the Oslofjord, Norway during winter and spring Adult females of Metridia longa inhabited the whole m deep-water column. Their distribution was shallower at night than during the day. Enumeration of egested faecal pellets suggested that feeding activity was greater at night than during the day and that more pellets were produced by individuals collected at shallow depths vs. There was no pronounced difference between months in feeding activity.

Although the hypothesis is that they prey on Calanus eggs and nauplii, scanning of Metridia faecal pellets by PCR using Calanus-specific primers did not confirm the presence of any Calanus prey DNA. Most pellets had a greenish colour, implying herbivorous feeding. Feeding is related to swimming, and the actively swimming Metridia would presumably be vulnerable to tactile invertebrate predators.

However, predation experiments where the carnivorous copepod Pareuchaeta norvegica was offered similar-sized Metridia and Calanus proved that Pareuchaeta consumed the less-active Calanus, but not the Metridia. Facile synthesis of Curcuma longa tuber powder engineered metal nanoparticles for bioimaging applications.

Sankar, Renu; Rahman, Pattanathu K. Nanomaterials based fluorescent agents are rapidly becoming significant and promising transformative tools for improving medical diagnostics for extensive in vivo imaging modalities.

Compared with conventional fluorescent agents, nano-fluorescence has capabilities to improve the in vivo detection and enriched targeting efficiencies. In our laboratory we synthesized fluorescent metal nanoparticles of silver, copper and iron using Curcuma longa tuber powder by simple reduction. The physicochemical properties of the synthesized metal nanoparticles were attained using UV-visible spectrophotometry, scanning electron microscopy with EDAX spectroscopy, dynamic light scattering, Fourier-transform infrared spectroscopy and X-ray diffraction.

The Curcuma longa tuber powder has one of the bioactive compound Curcumin might act as a capping agent during the synthesis of nanoparticles. The synthesized metal nanoparticles fluorescence property was confirmed by spectrofluorometry. When compared with copper and iron nanoparticles the silver nanoparticles showed high fluorescence intensity under spectrofluorometry.

Moreover, in vitro cell images of the silver nanoparticles in A cell lines also correlated with the results of spectrofluorometry. These silver nanoparticles show inspiring cell-imaging applications. They enter into cells without any further modifications, and the fluorescence property can be utilized for fluorescence-based cell imaging applications. Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists.

Curcuma longa has well-known insecticidal and repellent effects on insect pests, but its impact on Trichoplusia ni is unknown. In this study, the compound ar-turmerone, extracted and purified from C. The role of natural sesamol and piperonal and synthetic [piperonyl butoxide PBO ] synergists under laboratory and greenhouse conditions were also evaluated.

The concentration of ar-turmerone in C. The compound ar-turmerone alone and the combination with PBO reduced larval weight on treated Brassica oleracea in the laboratory and in greenhouse experiments, compared with the negative control. The compound ar-turmerone could be used as a low cost botanical insecticide for integrated management of cabbage looper in vegetable production.

Jayakumar, Vasanthan; Damodaran, Anand C. Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. Curcumin, a secondary metabolite isolated from the rhizomes of this plant has been shown to have significant anticancer properties, in addition to antimalarial and antioxidant effects. We sequenced the transcriptome of the rhizome of the 3 varieties of Curcuma longa L.

Multiple databases were used to obtain a comprehensive annotation and the transcripts were functionally classified using GO, KOG and PlantCyc. Special emphasis was given for annotating the secondary metabolite pathways and terpenoid biosynthesis pathways.

We report for the first time, the presence of transcripts related to biosynthetic pathways of several anti-cancer compounds like taxol, curcumin, and vinblastine in addition to anti-malarial compounds like artemisinin and acridone alkaloids, emphasizing turmeric's importance as a highly potent phytochemical.

Our data not only provides molecular signatures for several terpenoids but also a comprehensive molecular resource for facilitating deeper insights into the transcriptome of C.

Full Text Available Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. Curcuminoid content of Curcuma longa L. Curcuminoid, consisting of curcumin, demethoxycurcumin and bis demethoxycurcumin, is the major compound in Curcuma longa L. It has been known to have a potent antioxidants, anticancer, antibacteria activity.

Those rhizomes needs to be dried beforehand which influenced the active compounds concentration. The present work was conducted to assess the curcuminoid content of C. Samples were collected and dried using freeze-drying and oven method. The latter is the common method applied in most drying method at herbal medicine preparation procedure. Curcuminoid as a bioactive compound in the sample exhibited no significant difference and weak significant difference in C.

It resulted that curcuminoid content showed no significant difference in both samples. This replied that curcuminoids content in both samples were stable into heating process. These results are useful information for simplicia standardization method in pharmaceutical products regarding to preparation procedure. Full Text Available Embora a carcinicultura seja uma atividade considerada positiva, estudos apontam seus impactos negativos referentes ao trabalhador, ao meio ambiente e ao uso descontrolado dos recursos naturais.

The aim of the study was to investigate the safety and anti-inflammatory effects of polysaccharide fraction F1 of Curcuma longa extract NR-INF in classical rodent models of inflammation. The anti-inflammatory activity of F1 was evaluated in acute carrageenan - induced paw edema; xylene - induced ear edema and chronic cotton pellet - induced granuloma models of inflammation.

Also, F1 at doses of In a chronic model, F1 at Overall results indicated that F1 of NR-INF significantly attenuated acute and chronic inflammation in rodent models. This study emphasizes on the importance of Curcuma longa polysaccharide's role in acute and chronic inflammation. Bioactive chemical constituents of Curcuma longa L. The present study was designed to identify the chemical constituents of the methanolic extract of Curcuma longa L. The methanolic extract was subjected to GC-MS analysis to identify the volatile constituents and the other part of the same extract was subjected to liquid column chromatographic separation to isolate curcumin.

The inhibition of cell growth in the hepatoma cell line and the cytopathological changes were studied. GC-MS analysis showed the presence of fifty compounds in the methanolic extract of C. The major compounds were ar-turmerone Degenerative and apoptotic changes were more evident in curcumin- treated hepatoma cells than in those treated with the methanol extract. Antitumor potential of the methanolic extract may be attributed to the presence of sesquiterpenes and phenolic constituents including curcumin 0.

Effect of gamma irradiation on curcuminoids and volatile oils of fresh turmeric Curcuma longa. Dhanya, R. In our earlier study a radiation dose of 5 kGy was reported to be suitable for microbial decontamination and shelf life extension of fresh turmeric Curcuma longa , while maintaining its quality attributes. In continuation of that work, the effect of gamma radiation on curcuminoids and volatile oil constituents in fresh turmeric was studied.

Fresh peeled turmeric rhizomes were gamma irradiated at doses of 1, 3 and 5 kGy. The curcuminoid content was slightly increased by gamma irradiation. No statistically significant changes were observed due to irradiation in majority of the volatile oil constituents. Extracts from turmeric Curcuma longa L. The present study evaluated the anti-inflammatory activity, cytotoxic effect and the underlying mechanism of a novel chemically modified, non-carbonyl compound enriched Curcuma longa L.

In a PI permeability assay, cell lines derived from acute myeloid leukemia were most sensitive to the cytotoxic effects of CMCE. The present study defines the mechanism underlying the action of CMCE and suggests a therapeutic potential for its use in sepsis and leukemia. Curcuma longa extract — Haldi: A safe, eco-friendly natural cytoplasmic stain. Background: Eosin is most widely used synthetic dye belonging to the xanthene group.

These dyes are efficient but are hazardous to human and animal health. With the increasing awareness of a green earth, it is advisable to use more of eco-friendly and biodegradable material which can be effectively achieved by the use of natural dyes obtained from plants and other natural sources. Turmeric, available as Curcuma longa domestic , has long been in use in the subcontinent as a spice and flavorin Full Text Available Background and Objectives: Curcumin belongs to ginger family, which is used as food and drug from ancient times.

Different studies have shown beneficial effects of curcumin on peptic ulcer, rheumatoid arthritis, asthma, and various types of cancer. In this study, the effect of different doses of Curcuma longa aqueous extract on memory retention and retrieval of mice, was investigated using passive avoidance apparatus.

In memory retention test, the curcumin extract was administered immediately after electric shock, while in the memory retrieval test, it was administered 24 h after receiving electric shock. The level of significance was considered p longa aqueous extract significantly increased memory retention and retrieval on the 4th day compared to blank and control groups.

Conclusion: According to the results of this study, it seems that Curcuma longa aqueous extract improves memory retention and retrieval in healthy mice. Health benefits of curcuminoids from C. Kinetic analysis revealed that using starch as the substrate, HPA exhibited an uncompetitive mode of inhibition with an apparent K i of 3. The study gains importance as BDMC could be a good drug candidate in development of new inhibitors of HPA and of functional foods for controlling starch digestion in order to reduce post-prandial hyperglycemia.

Effects of curcumin Curcuma longa on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling.

Aging is a progressive process, and it may lead to the initiation of neurological diseases. In this study, we investigated the effects of wild Indian Curcuma longa using a Morris water maze paradigm on learning and spatial memory in adult and D-galactose-induced aged mice. In addition, the effects on cell proliferation and neuroblast differentiation were assessed by immunohistochemistry for Ki67 and doublecortin DCX respectively.

The administration of C. In addition, the administration of C. These results indicate that C. From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation. The aim was to evaluate the activity of seven medicinal, anti-inflammatory plants at the hH 4 R with focus on defined chemical compounds from Curcuma longa.

From the methanolic extract of C. Compounds from C. They exhibited estimated K i values of 4. The estimated K i value of the crude extract of curcuma was 0. Fractionated curcumin and the crude extract surpassed the effect of pure curcumin with a K i value of 5. Within this study, defined compounds of C. The mode of anti-inflammatory action of curcumin was further elucidated and the role of extracts in traditional phytomedicine was strengthened.

Curcuma longa extract - Haldi: A safe, eco-friendly natural cytoplasmic stain. Eosin is most widely used synthetic dye belonging to the xanthene group. Turmeric, available as Curcuma longa domestic , has long been in use in the subcontinent as a spice and flavoring agent in most food preparations.

Its health benefit as a natural antibiotic and anti-inflammatory has been successfully established by several researchers. The intense yellow color imparted by turmeric inspired us to explore its efficacy as a potential alternative for eosin in routine histopathological procedures. The aim of this was to explore the efficacy of turmeric extract as a stand-alone counterstain for hematoxylin and its comparative assessment with routine H and E staining.

This powder was dissolved into alcohol and centrifuged using a centrifugal machine. The supernatant was then collected with the help of micropipette. This supernatant was used as a counterstain for hematoxylin. Although eosin is the most efficient counterstain for hematoxylin, turmeric can also be used as an alternative for eosin. There are epidemiological pieces of evidence in experimental and observational population studies that confirm that ultraviolet radiation is the initial unleashing factor in occurrence of pterygium and a significant risk factor for its development.

The physical and climate phenomena accounting for the pathogeny of pterygium are almost unknown. Pterygium epidemiology is a basic tool for identifying its incidence and prevalence. On the basis of this review, we intended to make reflections on pterygium as a marker of degree of insolation of the human body and to emphasize the importance of protection against possible exposure to ultraviolet radiations in the final outcome of pterygium surgery.

Development of somatic embryos for genetic transformation in Curcuma longa L. Their shoots were cultured on MS medium supplemented with various concentrations of one of two plant growth regulators or a combination of both—2,4-dichlorophenoxyacetic acid 2,4-D and naphthaleneacetic acid NAA.

Somatic embryo formation reached The best conditions for the formation of shootlets occurred after transferring the somatic embryo to MS medium supplemented with 3. The shootlets were rooted by transferring to MS medium containing 3. This is the first report of a complete in vitro regeneration system from somatic embryos of C. Diketide CoA synthase DCS and curcumin synthase CURS genes, which are the two genes involved in curcuminoid biosynthesis in turmeric, were cloned and transferred to these two species using Agrobacterium-mediated transformation.

The presence of both target and marker genes, hpt, in the transformed somatic embryos was confirmed by polymerase chain reaction assay. After culturing, the transformed somatic embryos could survive for 4 weeks. Essential oil from waste leaves of Curcuma longa L. Its leaves are a waste material after harvesting rhizomes.

The aim of the study was to evaluate the chemical and pharmacological profile of essential oil from waste leaves of Curcuma longa EOCl against skin inflammation. EOCl was subjected to gas chromatography GC analysis for identification of essential oil constituents and its anti-inflammatory evaluation through in vitro and in vivo models.

These findings of topical anti-inflammatory properties of EOCl provide a scientific basis for medicinal use of this plant material against inflammatory disorders. Curcuma longa Linn. The HgCl 2 administration altered various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides and cholesterol contents with a concomitant decline in protein and albumin concentration in serum which were restored towards control by therapy of Curcuma longa or curcumin.

On the other hand, both treatments showed a protective effect on drug metabolizing enzymes viz. Choleretic, 1,1-diphenylpicryl-hydrazil DPPH -free radical scavenging activities and histological studies also supported the biochemical findings.

The present study concludes that Curcuma longa extract or curcumin has the ability to alleviate the hepatotoxic effects caused by HgCl 2 in rats. Os leites crus foram categorizados em grupos de CCS de baixa This study aimed to evaluate the effect of somatic cell counts SCC in milk on plasmin and plasminogen activities of ultra high temperature UHT milk during storage.

Raw milks were categorized in SCC groups of low ,, cells mL-1 and high cells ,, cells mL Two replicates of UHT milks within each SCC category were analyzed for plasmin and plasminogen activities after 10, 30, 60, 90 and days of storage at room temperature. For manufacture of UHT milk, raw milk was pasteurized and sterilized by direct vapor injection process, followed by aseptic packaging.

SCC had no effect on physical-chemical characteristics of raw milk, and on plasmin or plasminogen activities in raw and UHT milks during days of storage. However, independently of the SCC in raw milk. To establish a new method for the extraction and separation of curcuminoids from Curcuma longa rhizome by cloud-point preconcentration using microemulsions as solvent. The spectrophotometry was used to detect the solubility of curcumin in different oil phase, emulsifier and auxiliary emulsifier, and the microemulsion prescription was used for false three-phase figure optimization.

The extraction process was optimized by uniform experiment design. The curcuminoids were separated from microemulsion extract by cloud-point preconcentration. Oil phase was oleic acid ethyl ester; Emulsifier was OP emulsifier; Auxiliary emulsifier was polyethylene glycol peg ; The quantity of emulsifier to auxiliary emulsifier was the ratio of 5: 1; Microemulsion prescription was water-oleic acid ethyl ester-mixed emulsifier 0.

The optimum extraction process was: time for The extraction rate of curcuminoids was Curcuminoids is soluble in this microemulsion prescription with good extraction rate. This method is simple and suitable for curcuminoids extraction from Curcuma longa rhizome. Synergistic mosquito-repellent activity of Curcuma longa , Pogostemon heyneanus and Zanthoxylum limonella essential oils. Mosquito repellents play an important role in preventing man-mosquito contact. In the present study, we evaluated the synergistic mosquito-repellent activity of Curcuma longa , Pogostemon heyneanus and Zanthoxylum limonella essential oils.

The mosquito repellent efficacies of three essential oils were evaluated separately and in combination under laboratory and field conditions. The mixture of the essential oils provided The synergistic repellent activity of the essential oils used in the present study might be useful for developing safer alternatives to synthetic repellents for personal protection against mosquitoes.

Published by Elsevier Ltd. Full Text Available The long pepper is considered a promising species because of offering the prospect of making Brazil self-sufficient in the production of safrole, an important essential oil used as a fixative for fragrances and having therapeutic properties. In establishing areas intended for the cultivation of this species, it is necessary to evaluate the physiological quality of the seeds used in the production of seedlings.

The objective was to determine the conditions of temperature and luminosity for the test of germination and vigor in seeds of the long-pepper. Development, characterization and cross species amplification of polymorphic microsatellite markers from expressed sequence tags of turmeric Curcuma longa L. A total of microsatellite repeats were detected from 12, EST sequences of turmeric after redundancy elimination. Mononucleotides were the most abundant class of microsatellite repeat in turmeric ESTs followed by trinucleotides.

The number of alleles detected ranged from 3 to 8 per loci. The developed markers were also evaluated in 13 related species of C. The polymorphic microsatellite markers generated from this study could be used for genetic diversity analysis and resolving the taxonomic confusion prevailing in the genus. Ultraviolet radiation response of two heterotropy Antarctic marine bacterial; Respuesta a la radiacion ultravioleta de dos cepas bacterianas marinas heterotrofas antarticas. Instituto Antartico Argentino.

Two Antarctic marine bacterial strains, were exposed to different irradiance of ultraviolet UV solar radiation using several experimental protocols and interferential filters. Los resultados mostraron que tanto la radiacion UV-A como UV-B produce efectos deletereos sobre las dos cepas bacterianas analizadas.

Aim: The aim of this was to explore the efficacy of turmeric extract as a stand-alone counterstain for hematoxylin and its comparative assessment with routine H and E staining.

Materials and Methods: The rhizomes of C. Conclusion: Although eosin is the most efficient counterstain for hematoxylin, turmeric can also be used as an alternative for eosin. Growing Wild in Tunisia. The oils extracted from the aerial parts of both species were rich in polyunsaturated fatty acids with the essential linolenic and linoleic acids being the most prominent compounds. Oleic and linoleic acids were the majors fatty acids in the roots of both species. Whatever the plant part analyzed and the species, the saturated fatty acids were predominantly composed of palmitic and stearic acids.

The antibacterial activity, minimum inhibitory concentration MIC and minimum bactericidal concentration MBC of the lipid extracts were determined against a panel of five bacterial strains. Back when I first met with the renowned Japanese biomolecular researcher, Dr. Tatsumasa Mae, we discussed a new form of CoQ10 that I thought would revolutionize both nutritional and anti-aging medicine. And it did. A couple of years later, I learned that I could increase the power of ubiquinol by adding a group of vitamin E related organic antioxidants called tocotrienols.

Especially when you combine both at the same time. I intend to keep taking Accel for the rest of my life. On a recent treadmill stress test, I was told that I did as well as several patients tested who were in their 20s.

I feel better and my mood is much calmer. I believe this can be attributed to Accel. Now I would not be without it. The Secret to Boundless Energy Revealed.

CoQ10 is so important because it burns brighter than other cellular fuels, like fat and sugar. It what your body burns when it needs to produce more energy faster on demand like nitro supercharges a race car.

Meet Al Sears, M. Al Sears, M. As a board-certified clinical nutritionist, strength coach, ACE-certified fitness trainer and author, he enjoys a worldwide readership. As the first U. Sears made history by bringing telomere biology to the general public. In , Dr. Sears was one of the first doctors to document the true cause of heart disease and expose the misguided and often fatal drugs-and-surgery approach to heart health.

Sears outlines the easy-to-follow solution that effectively eliminates your risk of heart disease, high blood pressure and stroke. An avid lecturer, Dr. Until recently, no one even imagined it was possible to influence the number of these generators in your cells. Just like kids have. But unlike the all-too-common scenario when children grow into tired, sickly adults, this breakthrough lets you sustain that same level of unbridled energy and power you had as a child.

Now you could have the power to keep your cells as fresh and robust as those of a five-year-old… for decades to come. That goes back to the days when there was only one lab in the entire U. Today, CoQ10 is one of the most widely used supplements on the market. And for good reason. When you lose your power generators, you become weak and helpless. Loss and damage to your mitochondria accelerates aging.

But mitochondria have their own supply of DNA. The compound that makes new mitochondria is known as pyrroloquinoline quinine or PQQ. Please, for your sake, give me a few minutes to show you how this new discovery will change the way you live every, single day.

Mitochondrial biogenesis is a fancy way of saying PQQ activates the genes that give birth to new power generators in your cells. Depending on the type of cell, you may have as few as two mitochondria per cell, or as many as 2, But as your mitochondria become damaged and weak, they die off, and you lose your capacity to make energy.